We are exploring the discovery of new chemical reactions, pathways, and strategies to develop a comprehensive, robust, and cost-effective methodology that will overcome the limits of biology and enable de novo chemical synthesis of any proteins found in nature or designed by humans. Combined with the technologies of in vivo functional analysis, biochemical reconstitution, structural biology, and drug development, our chemical protein synthesis methodology will support the study of human biology and health from a unique perspective, and facilitate the development of precision diagnostics and therapeutics.